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One of the reasons why CBG is not widely known outside of the industry is due to the fact that only a small percentage of it is present in most cannabis strains by the time they reach maturation. Typically, there is less than 1% CBG in any given plant, which is why CBG is classified as a minor cannabinoid. As one 2018 study states:
Cannabigerol was isolated, characterized and synthetized by the same researchers that reported the structure of the main psychotropic agent of Cannabis, Δ9-THC. Few years later in vivo assays showed that CBG was non-psychoactive. The lower concentration and the lack of psychoactivity was probably the cause that CBG was shadowed by Δ9-THC. In fact, CBG has attracted less attention than Δ9-THC and even more than CBD, but nowadays is gaining interest among the scientific community.
Throughout the various growth stages, the cannabis plant is primarily composed of what’s known as cannabigerolic acid (CBGA). In the later stages, CBGA is eventually broken down by natural enzymes and turned into one of three cannabinoid lines:
Once these are exposed to ultraviolet light or heat, they primarily turn into either THC or CBD, with a small portion converting into CBG. And, for the vast majority of strains, the CBGA is instantly turned into either CBDA or THCA. As a result, a higher percentage of THC indicates the presence of smaller quantities of CBG and CBD, and a higher percentage of CBD indicates the presence of smaller quantities of CBG and THC.
So, to produce higher percentage yields of CBG, plant breeders have recently started to tinker with experiments such as cross-breeding strains or extracting of CBG at its peak point during the flowering cycle.
While both of these compounds are cannabinoids, they have different functions and may be helpful in reducing the symptoms of disparate ailments. Despite this, they share numerous similarities and there appears to be several places where therapeutic overlap can occur.
Both are free of psychoactive compounds, which makes them non-intoxicating. In addition, thanks to their strong interaction with the CB1 receptor, they both work to counteract the psychoactive effects of THC. So, if you were to theoretically smoke weed and then consume a CBG isolate, it would likely inhibit the “high,” at least to a degree. Ministry of Hemp writes:
Though the effects of CBD and CBG when combined haven’t been studied, we do know that combining different cannabinoid chemical compounds results in what’s called the entourage effect. This means that each cannabinoid’s effects are enhanced when they’re combined. This effect has been well-studied relating to the relationship between CBD and THC; for example, both CBD and THC are more effective at reducing pain when taken together.
As a result, full-spectrum CBD may often contain CBG in order to magnify its therapeutic properties.
While there haven’t been extensive human studies or trials conducted on CBG, the results of early research and animal studies have been promising. They point to the fact that concentrated CBG could have significant therapeutic benefits, and be used to assuage the following conditions and/or their various symptoms:
So, although there is still plenty of groundwork to be done, medical researchers and scientists are wildly optimistic about the potential uses for CBG going forward.
The information we’re gleaning on CBG’s potentially miraculous uses is growing by the day. All signs indicate that it may end up being as important of a therapeutic cannabinoid as CBD. So if you’re looking for CBG oil for sale, Plant People has the CBD products for you. Their organically-grown, full-spectrum hemp extracts are rich in cannabinoids, including CBG, CBD, and CBN. Each product is vegan, non-GMO, gluten-free, and lab tested.
NCBI. Cannabis, a complex plant: different compounds and different effects on individuals. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
Healthline. A Simple Guide to the Endocannabinoid System. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
Ministry of Hemp. CBD vs CBG: Comparing The Many Benefits Of CBD & CBG. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. A comparison of the ocular and central effects of delta 9-tetrahydrocannabinol and cannabigerol. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
British Journal of Pharmacology. Cannabinoids in Biology and Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586
NCBI. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736954/#bibr41-2045125312457586